Scotland midfielder James Morrison looks set to miss Saturday's World Cup qualifying opener in Macedonia.
The West Brom player, 22, suffered a knee injury in his club's goalless draw at Bolton on Saturday and has been unable to train since.
He had been in contention to start the Group Nine clash in Skopje, but coach Steven Pressley said: "I wouldn't think so. James is still struggling. We will give him every opportunity, but he is a major doubt."
Celtic's Barry Robson has been tipped to replace Morrison if he fails to recover.
"He hasn't featured a great deal for Celtic so far this season, but the way he played at the end of last season suggested that he is a very good midfielder and that's the reason he is in the squad," Pressley said. "He would bring a lot to the team and he's in our thoughts for the game."
Scotland's stand-in captain, Stephen McManus, has also been carrying an injury, but Pressley confirmed the Celtic defender had recovered from his ankle problem.
"He trained the last few days," the coach said. "Obviously, he got a knock in the Old Firm game, but he has shown no effects from that and he'll be fine."